What are the keys to a good sounding blues rig (guitar, amp, effects, etc.)?

I currently have a custom tele (which I love!) and just a simple 2x12 Crate amp (with tube preamp). I have a couple of overdrive pedals, a Line6 DL4, and a Big Muff Pi. Does anyone have any ideas about EQ, or any other pedals I should try? I've been playing guitar for quite a few years, but I am just getting into blues.